摘要
目的 探讨内毒素、肿瘤坏死因子 (TNFα)、白介素 6(IL 6)、白介素 8(IL 8)及一氧化氮(NO)在长时间重度失血性休克中的作用。方法 4 0只家兔随机分为对照组及失血性休克 1h、4h、8h组 ,从股动脉放血造成失血性休克 ,测定各组动物血浆内毒素、TNFα、IL 6、IL 8及NO水平。结果 血浆内毒素、TNFα、IL 6、IL 8及NO水平在休克后明显升高 (P <0 .0 1) ;血浆NO-2 活性水平以休克 1h组最高 ,但与休克 4h、8h组相比无显著差异 (P >0 .0 5 ) ,休克 4h组与休克 8h组NO-2 含量呈逐渐下降趋势。随着休克时间的延长 ,各组动物的存活率明显下降。结论 长时间失血性休克可使血浆内毒素、细胞因子及一氧化氮水平升高 。
Objective To stud y the role of endotoxin,tumor necrosis f actor α(TNF α),IL 6,IL 8 and NO in serio u s bleeding shock.Methods 40 rabbits were divided into 4 groups,inclu ding control group,1 hour shock group,4 hours shock group and 8 hours shock grou p random.The shock model was made by ble eding in hip artery.The the plasma level s of endotoxin,TNFα,IL 6,IL 8 and NO wer e measured in different group.Resu lts The plasma levels of endotoxin ,IL 6,IL 8 and NO increased obviously fo llowing bleeding shock (P<0.001) .The highest plasma level of NO was in 1 hou r shock group,but there were no obvious difference between 1hour shock group a nd other groups(P>0.05).The number of alive rabbit decreased with the prolong ation of bleeding shock.Conclusion s A long time and serious bleeding shock can induce the increase of endoto xin,IL 6,IL 8 and NO,the number of alive animal depends on the plasma levels of these inflammation factors.
出处
《前卫医药杂志》
2001年第5期328-329,共2页
Qianwei Journal of Medicine & Pharmacy
