摘要
目的 研究灯盏花素对沙土鼠缺血再灌注后海马延迟性神经元死亡的影响。方法 脑缺血 10分钟建立沙土鼠缺血再灌注模型。 32只沙土鼠分为假手术组、对照组、灯盏花素 10mg/kg组和灯盏花素 2 0mg/kg组。应用开阔法检查观察各组沙土鼠行为变化 ,应用病理检查判断脑缺血后神经细胞延迟性死亡情况。结果 灯盏花素明显减轻脑缺血后沙土鼠行为受损程度 ,减少海马CA1区锥体细胞的死亡数目。
Objective To investigate the protective effect of erigeron on the delayed death of the hippocampal neurons after ischemia reperfusion.Methods To prepare the gerbils model of forebrain ischemia reperfusion by 10min ischemia.32 gerbils were divided into 4group:sham operation group,cerebral ischemia group,erigeron 10mg/kg group and erigeron 20mg/kg group.Open field test and morphological evaluation were used to assess hippocampal ischemia injury.Result Erigeron ameliorated neurologic deficits in open field test and increased the survival numbers of the pyramidal cell in the hippocampus CA1 in gerbils.Conclusion Erigeron can decrease DND after cerebral ischemia in gerbils. [
出处
《临床麻醉学杂志》
CAS
CSCD
2001年第11期622-624,共3页
Journal of Clinical Anesthesiology
基金
江苏省卫生厅科研基金资助课题 (NoZ9717)
