摘要
新灯盏花素是植物灯盏花中一种有抗血小板作用的复盐成分。在家兔的主动脉血栓模型中能减轻血小板的破坏与5-羟色胺释放反应,对血栓形成有明显的抑制作用,这种作用与剂量呈正相关性。新灯盏花素对血小板与血管内皮细胞的花生四烯酸代谢物TXB_2与6-酮-PGE1α的生成均有抑制作用。试验结果表明该药在体内有强烈的抗血栓效应。
New-Breviscapine is an anti-platelet compound with some kinds of salts extracted from a Chinese herb Erigeron breviscapus.In aortic thrombus formation in rabbits,the platelet 5-HT release reaction and platelet destruction could be reduced by the compound,meanwhile aortic thrombosis was inhibited with a clear correlation between drug dosage and its efficacy.It was shown that new-breviscapine could inhibit the production of TXB_2 and 6-keto-PGF_1 α by platelets and endothelial cells respectively.The data suggest that new-breviscapine has a significant inhibitory effect on thrombus formation in vivo through suppression of platelet functions.
