摘要
目的:观察灯盏细辛注射液对急性脑梗死患者血管内皮功能及神经功能缺损程度的影响。方法:选择轻中度急性脑梗死患者87例,采用信封卡片法随机分为灯盏细辛注射液治疗组42例和对照组45例,两组基础治疗相同,治疗组使用灯盏细辛注射液40 m l,对照组用丹参注射液16 m l治疗,均以14 d为1个疗程,共用药2个疗程。比较两组治疗后循环内皮细胞(CEC)、血浆内皮素(ET)和降钙素基因相关肽(CGRP)水平以及神经功能缺损程度评分(NDS)的变化。结果:14 d时,治疗组血浆CEC、ET水平〔(8.0±3.6)个/0.9μl和(52.92±4.52)ng/L〕均低于对照组〔(10.2±3.3)个/0.9μl和(60.12±3.23)ng/L,〕CGRP高于对照组〔(65.23±1.52)ng/L比(60.12±2.14)ng/L〕,两组比较差异均有显著性(P<0.05或P<0.01);14 d和28 d时,治疗组NDS明显较对照组减轻〔14 d NDS:(15.9±3.6)分比(20.4±4.2)分;28 d NDS:(12.3±2.9)分比(15.3±4.2)分〕,差异均有显著性(P<0.01和P<0.05)。结论:灯盏细辛注射液通过调节急性脑梗死患者的血管内皮功能,可改善患者的预后。
Objective： To observe the influences of Dengzhan Xixin injection （灯盏细辛注射液） on vascular endothelial function and neurological deficit extent in patients with acute cerebral infarction. Methods. Eighty -seven patients with mild to moderate acute cerebral infarction were randomly divided into Dengzhan Xixin injection treatment group （treatment group, 42 cases） and control group （45 cases） by the random method of envelope and card. The patients in both groups were treated with the same basic therapy. The treatment group was treated with 40 ml of Dengzhan Xixin injection, and the control group was treated with 16 ml of salvia mihiorrhiza injection. The therapeutic course was 14 days in both groups and 2 courses were applied. The changes of circulating endothelial cell count （CEC）, the levels of endothelin （ET） and caleitonin gene- related peptide （CGRP） in plasma as well as neurological deficit were measured and compared. Results： The plasma CEC, ET in treatment group [（8.0 ± 3.6） cells/0. 9μl and （52.92± 4, 52）ng/L] were significantly lower than those in control group [（10. 2 =h 3.3）cells/0.9μl and （60.12±3.23）ng/L], but the plasma CGRP was higher than that in the control group on 14 th days [（65.23± 1.52）ng/L vs. （60. 12±2. 14）ng/L]. The differences were significant between the two groups （P〈0. 05 or P〈0. 01）. The neurological deficit extent in treatment group was more obviously alleviated than that in control group on 14 th and 28 th days [14 th day： （15.9±3.6）scores and （20.4± 4.2）scores; 28 th day： （12. 3 ± 2. 9）scores and （15.3 ± 4.2） scores]. The differences were significant between the two groups （P〈0. 01 and P〈0. 05）. Conclusion： Dengzhan Xixin injection is able to improve the prognosis of patients with acute cerebral infarction by means of regulating endothelial function.
出处
《中国中西医结合急救杂志》
CAS
2006年第1期6-8,共3页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
基金
广东省中医药局科研基金资助项目(1040100)
关键词
脑梗死
急性
灯盏细辛注射液
内皮素
降钙素基因相关肽
acute cerebral infarction
Dengzhan Xixin injection
endothelin
calcitonin gene -relatedpeptide
