摘要
目的 探讨人细小病毒B19(HPVB19)感染在再生障碍性贫血 (AA)发病中的作用。方法 应用巢式聚合酶链反应技术检测 2 2例AA患者外周血中HPVB19-DNA。结果 病例组HPVB19-DNA阳性 7例 (阳性率 31 8% ) ,与正常对照组比较有非常显著性差异 (P <0 0 1) ;而急性AA(AAA)与慢性AA(CAA)比较 ,HPVB19-DNA阳性率差异无显著性 (P >0 0 5 )。结论 AA患者中HPVB19感染率较高 。
Objective To explore the role of human parvovirus B19(HPV B19) infection in the onset of aplastic anemia(AA).Methods The presence of HPV B19-DNA was detected in the peripheral blood samples from 22 patients with AA(aplastic anemia) by using nested polymerase chain reaction assay,and 20 healthy blood donors as control.Results Seven of 22(31 8%) AA cases were HPV B19-DNA positive,while all the samples from the control group were negative for HPV B19-DNA (P<0 01).Furthermore,there was no remarkable difference between acute AA(AAA) and chronic AA(CAA) in HPV B19-DNA positive patients(P>0 05).Conclusion HPV B19 infection is closely related to the onset of AA,and may be an important viral cause for AA.
出处
《中国医师杂志》
CAS
2001年第9期588-589,共2页
Journal of Chinese Physician
基金
军队留学回国人员启动基金 (9470 0 8)
第四军医大学科技创新工程 (CX99A0 0 8)资助项目
