摘要
在抗肿瘤免疫应答中 ,关键的一步是抗原呈递细胞将肿瘤抗原呈递给 T淋巴细胞。树突状细胞是专职抗原呈递细胞 ,它能够有效的将肿瘤抗原呈递给 T细胞 ,引发机体产生抗肿瘤的免疫应答。因此 ,利用树突状细胞制备肿瘤疫苗可望提供一种有效的肿瘤免疫治疗方法。目前 ,体外实验、动物实验和初期的临床实验都已经证明了树突状细胞肿瘤疫苗的抗肿瘤作用。本文主要介绍树突状细胞的生物学特征和树突状细胞肿瘤疫苗在肿瘤免疫治疗中的研究进展。
It is a key step that APCs present tumor antigens to T lymphocytes during anti tumor immune responses DCs are professional APCs that are able to initiate and activate anti tumor immune responses efficiently Thereby, it is promising to make tumor vaccines based on DCs Up to now, the anti tumor functions of DCs vaccines have been demon strated in vitro , in animal models and early clinical trials This review is focused on the biological characteristics of DCs and advances in DCs tumor vaccines
出处
《免疫学杂志》
CAS
CSCD
北大核心
2001年第6期475-477,共3页
Immunological Journal
关键词
树突状细胞
抗原呈递细胞
主要组织相容性复合体
细胞毒性T淋巴细胞
肿瘤疫苗
dendritic cells(DCs)
antigen presenting cells(APCs)
major histocompatibility complex(MHC)
cytotoxic T lymphocytes(CTLs)
tumor vaccine
