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紫外线诱导皮肤肿瘤形成机制 被引量：3

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摘要 在紫外线相关皮肤肿瘤的形成过程中 ,机体的免疫系统发挥着重要的作用。本文综述了紫外线改变皮肤免疫功能机制的研究进展。这些研究表明 ,受紫外线照射的皮肤不仅在受照射部位产生原位的、非特异性的抑制免疫受体功能的免疫抑制 ,而且当暴露于紫外线一定时间后也会产生全身性的、抗原介导的特异性的免疫抑制。其中 ,紫外线造成DNA的直接损伤是形成紫外线相关皮肤肿瘤的关键一步。
作者 尹锐 刁庆春 刘荣卿
机构地区 第三军医大学西南医院皮肤科
出处 《国外医学（皮肤性病学分册）》 2001年第5期276-278,共3页 Foreign Medical Sciences(Section of Dermatology and Venereology)
关键词 紫外线 诱导 免疫抑制 皮肤肿瘤
分类号 R739.5 [医药卫生—肿瘤]
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参考文献20

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  • 2Duthie MS, Kimiber I, Norval M. The effect of ultraviolet radiation on the human immune system. Br J Dermatol, 1999,140(6) :995-1009.
  • 3Donawho C, Evans R, Kripke ML. Immunobiology of primary murine melanomas. J Immunother, 1992,12(3): 187-193.
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同被引文献13

  • 1Johnston KJ. Ultraviolet radiation induced connective tissue change in the skin of hairless mice [ J ]. J Invest Dermatol,1984, 82:587 - 591.
  • 2Pand Bs, Parrish JA. The interaction of UVA and UVB in the prtxtuction of threshold erythema[ J]. J Invest Dermatol,1982, 78:371.
  • 3Duthie MS, Kimber I, Norm M. The effect of ultraviolet radiation on the human immune system[ J ]. Br J Dermatol,1999, 140(6) :995 - 1009.
  • 4Sarasin A. The molecular pathways of ultraviolet- induced carcinogenesis, Mutat Res, 1999, 428(1 -2):5- 10.
  • 5Simon JC, Tigelear RE, BergstresserPR, et al. Ultraviolet B radiation corwerts, langerhans cells from immunogenic to tolerogenic antigen - presenting cells induction of specific clonal anergy in CD4+ T helper- 1 cells[J]. J Immmol,1991,146(2) :485 - 491.
  • 6Matsuoka LY, Wortsman J, Havifan N, et al. Chronic suncream use decreases circulation concentration of 25 -hydroxyritam in D[J]. Arch Dermatol,1988,124:1802.
  • 7方方 林皆鹏 陈建良.着色性干皮病继发三种肿瘤一例[J].中华皮肤科杂志,2000,33(1):63-63.
  • 8赵宗群.紫外线对皮肤影响的流行病学研究[J].环境与健康杂志,1999,16(4):245-247. 被引量：9
  • 9倪建华,周华,戴修道.防晒化妆品和它的功能评价[J].中国公共卫生,2000,16(4):373-374. 被引量：7
  • 10常建民,朱铁君.紫外线引起皮肤色素沉着的机制[J].国外医学（皮肤性病学分册）,2000,26(6):334-336. 被引量：6

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二级引证文献16

国外医学（皮肤性病学分册）
2001年 第5期

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