摘要
目的观察大鼠脑缺血再灌注后海马组织AchE活力的动态变化.方法阻断大鼠双侧颈总动脉进行脑缺血再灌注,于术后第1,7,15 d用比色法测海马组织AchE活力.结果第1,7 d模型大鼠AchE活力分别是(170.95±10.44)mmol·L-1,(168.34±12.02)mmol·L-1,较正常组明显降低(P＜0.01),且7 d组AchE活力低于1 d组,随着缺血再灌注损伤的修复,15 d组AchE活力明显回升.结论 AchE活力降低在缺血再灌注脑损伤中起重要作用.
Objective To observe dynamic changes of AchE activities of hippocampal in rats with cerebral ischemia reperfusion.Methods AchE activities were respectively assayed by colorimetric method on the 1st,7th and 15th day after cerebral ischemia reperfusion by common carotid artery occlusion.Results AchE activities were respectively (170.95±10.44)mmol·L -1 on the 1st day and(168.34±12.02)mmol·L -1 on the 7th day,which significantly decreased compared with control ( P <0.01).AchE activity on the 7th day was lower than that on the 1st day. With the injury of ischemia reperfusion recovering, AchE activity was significantly increased on the 15th day.Conclusion Decreasing of AchE activity have an important effect on cerebral ischemia reperfusion.
出处
《北华大学学报（自然科学版）》
CAS
2001年第5期369-370,共2页
Journal of Beihua University（Natural Science）
基金
河北省科委资助项目 (986 187D)
