摘要
目的 :探讨黄体酮对缺血再灌注性脑损伤小鼠学习记忆功能的影响。方法 :将小鼠分为假手术组和缺血再灌注组进行各项指标的观测。结果 :水迷宫试验和跳台试验测定均显示 :生理盐水组与假手术组相比 ,出现明显的学习记忆障碍。与生理盐水组比较 ,高剂量组到达终点时间、错误次数及 2min内到达终点动物比率均有显著性差异 ,中剂量组错误次数有显著性差异。生理盐水组与假手术组比较 ,乙酰胆碱 (Ach)含量明显减少 ,胆碱脂酶 (AchE)活力明显增加。与生理盐水组比较 ,高剂量和中剂量黄体酮组Ach含量明显增加 ,而AchE活力明显降低。结论 :黄体酮对缺血再灌注脑损伤后小鼠的记忆功能有保护作用。
Objective: To study the influence of progesterone on mice’s studying and memory function in cerebral ischemia-reperfusion injury. Methods: Dividing the mice into sham group and ischemia-reperfusion groups, then observing the indexes. Results: The trial both of water labyrinth and jumping stand showed that the saline group had occured the significant disorder in studying and memory in comparison with the sham group. There was significant difference between the saline and the high doses group in the time of reaching destination, the times of error number and the animals' ratio of reaching destination in two minutes. The content of acetylcholine decreased and the activity of cholinesterase increased significantly in saline group in comparison with sham group and the same to the middle and the high doses group. Conclusions: There are protective function of progesterone to mice's studying and memory function in cerebral ischemia-reperfusion injury.
出处
《牡丹江医学院学报》
2003年第4期1-3,共3页
Journal of Mudanjiang Medical University
