摘要
目的 :研究 N-苯基哌嗪的合成方法。方法 :以苯胺、二乙醇胺等为起始原料 ,采用两条路线 :路线 A是通过溴化、缩合、中和等反应来合成目标产物 ,路线 B采用“一锅煮”方法制备所需的化合物。结果 :路线 A的收率为 2 7.8% ,路线 B的收率为47.2 % ,含量均在 96%以上 ,1 H- NMR谱表明结构正确。结论 :路线 B的工艺流程简单 ,三废少且易处理 ,该路线适合于工业化生产。
OBJECTIVE:To study the synthetic methods of N phenyl piperazine.METHOD:Using aniline and diethanolamine as starting materials,N phenyl piperazine was synthesized by two routes. Target compound was synthesized after bromination,condensation and neutralizaton reactions in method A. The final product was prepared after 'one pot'reaction in method B.RESULTS:The yield of method A was 27.8% and method B gave 42.2%. The purity of the products was over 96% by analysis of HPLC. 1H NMR showed the structure of product was correct.CONCLUSION:Method B for producing N phenyl piperazine was a more convenient manipulation in shorter time with less pollution comparing with method A,and we adopted method B for scale production.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2001年第5期372-374,共3页
Chinese Journal of Modern Applied Pharmacy
基金
浙江省自然科学基金资助 (编号 :B0 2 0 5 0 1)
