摘要
目的：探讨P－gp、GST－π、TopoⅡ在食管癌组织中的表达及意义。方法：采用免疫组织化学方法研究了P－gp、GST－π、TopoⅡ在食管癌组织中的表达情况。结果：P－gp、GST－π在食管癌组织中的表达升高，表达率分别为58．02％和72．84％，P－gp 的高表达与淋巴结转移、癌肿浸润深度有关P＜0．05。GST－π的高表达与细胞分化程度有关P＜0．05。TopoⅡ在食管癌组织中的表达降低，表达率为61．73％，TopoⅡ的表达降低与临床病理参数无关P＞0．05。结论：食管癌组织中存在着P－gp、GST－π、TopoⅡ表达水平的变化，临床检测P－gp、GST－π、TopoⅡ对食管癌化疗方案的制定、判断预后有重要的指导意义。
Objective To study the expression of P－gp.GST－π.Topo Ⅱ in esophageal carcinoma and its correlation to clinicopathological features． Methods The exspression patterns of P－gp.GST－π.Topo Ⅱ in 81 patients with esophageal carcinoma were examined by iummunohistochemistry SP method using monoclonal antibody to their protein． Results The positive rates of P－gp.GST－πand Topo Ⅱ were 58．2％.72．84％ and 61．73％ respectively． High P－gp was more frequently observed in patients with lymph node metastasis and in cancers with deep－muscle and fibro－membrane infiltration P＜0．05． High GST－πwas more often associated with poor－differentiated than well－differentiated cancers P＜0．05． Topo Ⅱ expression was not related to the clinicopathological features P＞0．05． Conclusion The results suggest that esophageal carcinoma express primary multidrug resistance genes． Detecting expression of P－gpGST－πand Topo Ⅱ might play an important role in chemotherapy strategy and might be a useful predictor of prognosis of esophageal carcinoma．
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2001年第6期434-435,438,共3页
Chinese Journal of Clinical Oncology
基金
辽宁省重点科技项目资助!00225003
