摘要
目的：探讨乳腺轻、中及重度乳头状瘤病与乳腺癌的相关性及其诊治策略。方法：对1993～1996年天津医科大学附属肿瘤医院乳腺科收治的87例乳头状瘤病病例的临床资料加以收集、整理，复习病理切片并重新做出病理诊断。结果：由于重度乳头状瘤病患者均接受全乳切除术，故术后无癌变发生。在31例轻度乳头状瘤病患者中亦未发现癌变病例。而在35例中度乳头状瘤病患者中，有5例于术后3～9年间因局部复发性肿物再次住院并被确诊为乳腺癌，病理类型多为浸润性癌。首次就诊时2例表现为局部肿物，2例为乳头溢血，1例为肿物伴溢血。3例有恶性肿瘤家族史，其中2例为母亲患乳腺癌。病理诊断方面，除1例细胞异型稍明显外，其余病例无特殊表现，均符合中度乳头状瘤病的病理诊断。结论：乳头状瘤病多以局部肿物或乳头溢液、溢血为首发症状，虽为良性病变，但有一定的癌变倾向，故应积极手术治疗。由于其病变范围广泛，手术切除范围应更广泛并行标本断端以确保病变的完整切除，降低癌变的发生率，尤其对于那些有高危因素的患者（如乳腺癌家族史），应密切随访观察。
Objective To explore the relationship between papillomatosis and breast cancer.and to introduce our experience of therapeutic scheme． Methods The clinical and pathological materials of 87 patients with papillomatosis from 1993 to 1996 were studied and the final pathological diagnoses were reviewed． Results Generally the mild papillomatosis or the severe papillomatosis of breast were treated with total mastectomy with very seldom carcinogenesis of the primary lesion． Five of 35 patients with moderate papillomatosis who were performed local resections had developed cancers within 3 to 9 years after first operation.the main symptoms of these patients were palpable mass and bloody discharge.and all had reoperations． Three of them had family malignant tumor history two patients family had history of breast cancer． Pathologically.except one case had heteromorphic cells.the others had only moderate papillomatosis without specific changes． Conclusion Although pappilomatosis is a benign lesion but it has the possibility of carcinogenesis.so vigorous measures should be adopted especially for the moderate papillomatosis with high risk such as family history of breast cancer）．
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2001年第6期425-427,共3页
Chinese Journal of Clinical Oncology
关键词
乳腺乳头状瘤病
癌变
诊断
治疗
Breast papillomatosis Carcinogenesis Diagnosis Treatment
