摘要
目的了解乳腺乳头状瘤病的生物学特性，重点观察其早期癌变及与大导管乳头状瘤的关系。方法对行全乳腺切除或根治术的重度乳头状瘤病１４例、乳头状瘤病癌变２２例进行次连续大切片病理组织学观察。结果两类病变分布均较广泛，分布在两个象限以上者分别占７１．４％（１０／１４）和６３．６％（１４／２２）。在乳头状瘤病癌变病例中，发现乳头状瘤病组织与癌组织常相互交错分布，可见前者移行为后者。两者伴发大导管乳头状瘤亦较常见。结论乳头状瘤病是乳腺癌的一种癌前病变，其与大导管乳头状瘤可能发生自同一致病因素。
Objective To investigate the characteristics of breast papillomatosis, its malignant transformation and relation with main ductal papilloma. Methods A histopathological study by en bloc breast subserial sections was performed on 14 cases of highly proliferative papillomatosis and 22 cases of carcinoma arising from the highly proliferative papillomatosis. Results The two types of lesions were widely scattered over the sections, covering more than two quadrants in 71.4%(10/14) and 63.3%(14/22) of the breast, respectively. Crisscross and histological transition of the two lesions were observed frequently in the sections of carcinoma arising from the highly proliferative papillomatosis. These two kinds of lesion often coexisted with main ductal papilloma. Conclusion Papillomatosis is a breast precancerous lesion and it may have similar pathogenetic mechanism as main ductal papilloma.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
1997年第4期290-292,共3页
Chinese Journal of Oncology
关键词
乳腺肿瘤
乳头状瘤病
病理学
癌前状态
Breast neoplasms/pathology Papillomatosis/pathology Precancerous conditions
