摘要
背景与目的:30岁以下青少年乳头状瘤病例较罕见,目前研究报道多见于高加索人种,国内此类报道较少,其与乳腺癌的关系尚不明确。本研究旨在了解中国青少年乳头状瘤的临床特点及与乳腺癌的关系。方法:对7例行手术治疗的30岁以下青少年乳头状瘤患者的临床病理及随访资料进行回顾性分析;患者均为女性,发病年龄11～29岁,中位年龄23岁;随访截至2010年12月31日,随访时间13～150个月,中位随访时间85个月。结果:青少年乳头状瘤患者以乳房肿块为主要表现,具有多灶性特征;除1例患者临床仅有乳头溢血、1例为肿物伴乳头溢血外,其余5例仅表现为乳房肿块;4例可触及多发肿物(占57.1%),其中1例肿物位于2个象限,1例为双侧乳腺肿块;7例患者临床及影像学诊断全部误诊;术后病理为重度乳头状瘤2例(占28.6%),为乳腺癌癌前病变,其中1例行全乳切除,病理证实除肿物外其他象限存在乳头状瘤病;随访中1例患者发生乳腺癌(占14.3%),此患者以多发肿物首次就诊,且具有乳腺癌家族史。结论:青少年乳头状瘤患者有较高的乳腺癌发生风险,乳腺癌家族史及多灶性病变是高危因素。
Background and purpose:Juvenile papillomatosis is a rare benign proliferative breast tumor that occurs in adolescence.Most reports on juvenile papillomatosis are found in Caucasians,with a few rare cases occurring in Chinese people.This study explored the clinical features of juvenile papillomatosis in Chinese people as well as the relationship between juvenile papillomatosis and breast cancer.Methods:A retrospective study was performed on 7 juvenile papillomatosis cases that underwent surgery from Jan.1998 to Dec.2009.All patients were female,11 to 29 years old,with a median age of 23-year-old.The data that was analyzed including family histories of breast cancer,clinical findings,surgery types and pathological characteristics.The postoperative follow-up were 13 to 150 months(the last follow-up was Dec.31st 2010),with a median follow-up period of 85 months.Results:The main clinical manifestation of juvenile papillomatosis was breast mass,and tend to be multiple.Of the 7 patients,5 had palpable breast masses without nipple discharge,1 had 1 breast mass with bloody nipple discharge,and 1 case with bloody nipple discharge only.Four patients(57.5% of all cases) had more than 1 mass,including 1 patient who had multiple masses in different quadrants of the breast and 1 patient who had simultaneous bilateral breast masses.All 7 patients were misdiagnosed using physical examinations and imageology findings.Two patients had highly proliferative papillomatosis(28.6% of all cases) after surgery,1 patient received mastectomy,and found papillomatosis in different quadrants at pathological examination.One patient had developed breast cancer,this patient had multiple breast masses upon initial diagnosis as well as a family history of breast cancer.Conclusion:Juvenile papillomatosis has a high risk of developing into breast cancer.Therefore,patients with a family history of breast cancer or multiple papillomatosis have especially high risks.
出处
《中国癌症杂志》
CAS
CSCD
北大核心
2011年第3期228-231,共4页
China Oncology
关键词
乳头状瘤病
乳腺癌
青少年
Papillomatosis
Breast carcinoma
Juvenile
