摘要
采用心钠素（ＡＮＰ）特异性放免分析方法，测定了３０例左向右分流先心病患者（实验组）和９例无心、肺疾患的普胸患者（对照组）的右房、肺动脉血浆ＡＮＰ的含量，并结合血流动力学参数进行分析。结果：（１）实验组血浆ＡＮＰ水平高于对照组（Ｐ＜０．０５）；（２）实验组血浆ＡＮＰ水平与右房压、右室压、肺动脉压及心内缺损大小呈正相关；（３）实验组血浆ＡＮＰ水平右房高于肺动脉（Ｐ＜０．０５）。表明左向右分流先心病患者血浆ＡＮＰ水平升高，与其血流动力学的改变有关，其右房可能是ＡＮＰ分泌的主要部位。
The plasma levels of ANP in blood collected from right atria (RA ) and pulmonary arterywere determined by sepcific radioimmunoassay in thirty patients with left-to-right shunt con-genital heart diseases(experimental group)and 9 patients without heart or pulmonary disease(control group),and and analyzed with hemodynamic parameters. The results showed:(1)plasma ANP level in the experimental group was higher that that in the control group(P<0. 05),(2)plasma ANP level of RA was positively correlated with right atrial pressure,rightventricular pressure,pulmonary arterial pressure and size of the defect,(3)plasma ANP levelof RA was higher than that of PA in the experimental group. It is suggested that the concen-tration of plasma ANP increases in patients with congenital heart disease, correlating withhemodynamic parameters,and that the RA might be the main secretory site.
出处
《江西医学院学报》
1994年第3期35-38,共4页
Acta Academiae Medicinae Jiangxi
关键词
先天性心脏缺损
血浆心钠素
放射免疫测定
血流动力学
heart defects,congenital
atrial natriuretic peptide
radioimmunoassay
comparative study
