摘要
目的 探讨血管内皮生长因子 (VEGF)与肺动脉高压形成和发展的关系。方法 运用临床流行病学原理和方法 ,对先天性心脏病 (先心病 )肺动脉高压 (肺高压 )病人血清VEGF进行分析。 1999年 3月至 8月间 ,5 1例先心病病人中 2 3例肺高压 ,平均肺动脉压 (38 70± 10 82 )mmHg;2 8例肺动脉压正常病人 ,平均肺动脉压 (16 42± 2 0 3)mmHg。采用酶联免疫吸附法测定 5 1例病人的血清VEGF浓度并分析计算。结果 肺高压组病人血清VEGF平均 (2 91 70± 197 6 6 )pg ml,肺动脉压正常组病人血清VEGF浓度 (38 5 6± 2 2 2 5 )pg ml,两组间差异有显著性 (P <0 0 1)。VEGF与肺动脉压呈正相关。结论 VEGF在肺动脉高压血管重构中起保护作用 ,先心病病人血清VEGF浓度升高 。
Objective To investigate the relationship between development pulmonary hypertension and vascular endothelial growth factor(VEGF). Method Serum VEGF concentration was measured by using enzyme linked immunosorbent assay. In 23 patients with pulmonary hypertension [mean pulmonary artery pressure was (38 70±10 82)?mm?Hg] and 28 patients without pulmonary hypertension [mean pulmonary artery pressure was (16 42±2 03)mm?Hg].Results Mean concentration of serum VEGF in patients with pulmonary hypertension was (291 70±197 66)?pg/ml, and (38 56±22 25)?pg/ml in patients without pulmonary hypertension. VEGF concentration and pulmonary artery pressure were positively correlated(r=0 714,4). Conclusion The serum VEGF concentration in patients with congenital heart disease associated with pulmonary hypertension is much higher than that in control group (P<0 01). VEGF is probably involved in the pathophysiology of pulmonary hypertension.
出处
《中华胸心血管外科杂志》
CSCD
北大核心
2000年第6期341-342,共2页
Chinese Journal of Thoracic and Cardiovascular Surgery
关键词
先天性心脏缺损
肺动脉高压
血管内皮生长因子
heart defects, congenital Endothelial grouth factor Endothelium, vasculat
