摘要
目的 探讨 p1 6、Rb蛋白在甲状腺癌发生、发展中的作用及其相互关系。 方法 采用免疫组织化学SP法对 46例甲状腺癌中 p1 6、Rb蛋白表达情况进行检测。 结果 在甲状腺癌中 ,p1 6蛋白的表达随肿瘤的恶性程度增高而降低 ,与淋巴结转移、临床分期及预后指数呈负相关。Rb蛋白在各型甲状腺癌中均呈阳性表达 ,p1 6、Rb表达无相关性。结论 p1 6基因的异常表达在甲状腺癌的发生、发展中有一定作用 ,而Rb基因可能无作用。
Objective To demonstrate the role of p16 protein and Rb protein in the formation and progression and their relationship in thyroid carcinoma. Methods p16 and Rb from 46 patients with thyroid cancer were detected by SP immunohistochemistry. Results In thyroid carcinoma,the p16 positive rate was decreased with the decline of differentiation. There was an inverse correlation between the rates of p16 positive expression and involvement of lymph node,clinical stage and prognosis index.The Rb protein was not present in any cases as a nucleus staining. Conclusion The p16 gene is likely to play an important role in the genesis and malignant progression of thyroid carcinoma,while the Rb gene is not .
出处
《中国普外基础与临床杂志》
CAS
2001年第5期319-321,共3页
Chinese Journal of Bases and Clinics In General Surgery
