摘要
为探讨ｐ１６，ｐ５３蛋白在胃癌发生、发展中的作用及其临床意义。应用免疫组化方法，对６０例胃癌、１８例胃良性疾病及１５例胃正常组织中ｐ１６，ｐ５３蛋白的表达情况进行检测。结果显示：胃癌组织中ｐ１６蛋白的阳性率（２５％）低于胃良性疾病（６１．１１％）及胃正常组织中的阳性率（６３．３３％），有显著性差异（Ｐ＜０．０５）；而胃癌组织中ｐ５３蛋白的阳性率（６１．６７％）高于胃良性疾病（１１．１１％）及胃正常组织（０），差异非常显著（Ｐ＜０．００１）。ｐ１６，ｐ５３蛋白的表达与胃癌的组织学分化、临床分期及淋巴结转移密切相关，与患者年龄、性别、肿瘤位置无关；ｐ１６蛋白表达还与肿瘤大小有关。研究结果表明，ｐ１６蛋白的失表达发生在胃癌发生、发展的晚期阶段，ｐ１６，ｐ５３蛋白可作为判别胃的良、恶性疾病及胃癌患者预后的一个指标。
To study the clinical significance and the effect of the expression of p16 protein and p53 protein in the occurence and development in gastric carcinoma, we detected the expression of p16 protein and p53 protein in 60 cases of gastric carcinoma, 18 cases of benign gastric diseases and 15 cases of normal gastric tissue with immunobistochemical method. The positive rate of p16 protein in gastric carcinoma (25%) was lower than that in benign gastric diseases and normal gastric tissue (P<0.05); the positive rate of p53 protein (61.67%) was higher than that in benign diseases and normal gastric tissue (P<0.001). The expressions of p16 and p53 protein were closely correlated to the tumor histologic type, degree of differentiation and lymph node metastasis. The results indicated that the low expression rate of p16 protein occurred in the advanced stage of gastric carcinoma. The expression of p16 and p53 protein might be a indictor for differentiating the benign from malignant gastric diseases and a prognosis indictor for the patient with gastric carcinoma.
出处
《中国普通外科杂志》
CAS
CSCD
1998年第3期161-164,共4页
China Journal of General Surgery
