摘要
Wistar大鼠每天腹腔注射醋酸铅 659mg/kg ,在第 4周醋酸铅剂量降至 3 2 9 5mg/kg ,8周停止染毒。结果表明 ,随着铅染毒 ,大鼠出现高尿铅、高尿锌、高尿钙 ;脑、肝、肾中铁、锌、钙却都有不同程度提高 ,肝脏中锌、钙、铁 ,肾脏中锌、钙增加极明显 ;在 8周停止染毒后 ,脑铅含量大幅度降低 (P <0 0 1 ) ,肝脏铅却梢有上升 (P >0 0 5) ,肾铅急剧增加 ,从 4 7 93 2 0μmol/L升至 63 3 .85μmol/L ,大约上升 1 3倍 (P <0 0 1 )。
Wistar rats were injected intraperitoneally with lead acetate in dosage of 659 mg/kg body every day.At the 4th week,the dosage of lead acetate was reduced to 329.5 mg/kg body.After the 8th week poisoning was stopped.The results show that the rats appear higher urinary Pb,Zn,Ca along with lead poisoning.Calcium,zinc and iron concentrations in brain,liver and kidney all rise to a certain extent.Liver calcium,zinc and iron,kidney calcium and zinc increase obviously(P<0 01).After the 8th week,brain lead decrease obviously(P<0 01).liver lead does not change obviously.Kidney lead raises extremely and rises about 13 times from 47 93 μmol/L to 633 85 μmol/L(P<0 01).
出处
《广东微量元素科学》
CAS
2001年第4期23-26,共4页
Trace Elements Science
