摘要
将９０只大鼠用醋酸铅溶液灌胃，当尿铅＞（０．８１±０．２６）ｍｇ／Ｌ，血铅＞（４．８±０．３３）ｍｇ／Ｌ时，随机分为３组，测定血清中氧化损伤的指标发现超氧化物歧化酶（ＳＯＤ）活性降低和丙二醛（ＭＤＡ）升高。用一种有机硒化合物（ＦＣＱＹ）灌胃后，ＳＯＤ活性明显升高，并有效地抑制脂质过氧化（ＭＤＡ降至正常范围）。将动物处死后，测定骨铅、肾铅和肝铅含量，发现该有机硒能干扰铅的吸收和蓄积。
Ninety white rats were treated with liquid lead acetate. when the concentration of lead in urine was more than (0 81±0 26) mg/L and blood lead was more than (4 8±0 33) mg/L, the rats were divided into three groups randomly. The oxygenic damage indicators in serum showed SOD activity decreased and MDA content increased. In one group of lead rats fed with an organic selenium compound (code FCQY) the SOD activities were high and the lipid peroxidation was inhibited compared with controls without selenium supplementation. The lead contents of bone, kidney and liver were measured. The results suggested that the organic selenium compound could interfere with the absorption and accumulation of lead.
出处
《卫生研究》
CAS
CSCD
北大核心
1998年第4期229-232,共4页
Journal of Hygiene Research
基金
青岛市科委资助
关键词
有机硒
铅中毒
拮抗作用
超氧化物歧化酶
organic selenium, lead poisoning, antagonistic action, superoxide dismutase, lipid peroxidation
