摘要
目的 探讨联合应用氯沙坦和吲哒帕胺对老年轻、中、度高血压病的疗效、顺应性及对靶器官损害的影响。方法 采用自身对照方法 ,观察氯沙坦联合吲哒帕胺对 5 7例老年高血压患者动态血压及代谢参数的影响。氯沙坦剂量为 5 0mg/d ,吲哒帕胺为 2 .5mg/d ,疗程为 4个月。结果 总有效率为 89.5 % ,治疗后 2 4h收缩期均压、舒张期均压、白昼收缩期均压、夜间收缩期均压、夜间舒张期均压有非常显著降低 (P <0 .0 1) ,白昼舒张期均有显著降低 (P <0 .0 5 ) ;治疗后血肌酐、血 β2 微球蛋白、尿α1微球蛋白显著降低 (P <0 .0 5 )。结论 氯沙坦和小剂量吲哒帕胺联合应用 ,对老年轻、中、高度血压疗效显著 ,作用平稳 ,不影响代谢 。
OBJECTIVE: To investigate the efficacy and safety of Losartan in combination with indapamide in elderly with essential hypertension. METHODS: 57 elderly patients with essential hypertension were treated with the combination of losartan and indapamide. 24 h ambulatory blood pressure monitoring and the metabolic parameters were observed. The total follow-up periods was 4 months. RESULTS: The total efficacy rate was 89.5%. There were significant reductions of 24 h MSBP,MDBP,dMSBP,nMSBP,nMDBP (P 1-MG were also significantly reduced (P < 0.05). CONCLUSIONS: The combination of losartan and indapamide for the treatment of essential hypertension in elderly was effective and safe.
出处
《中国药学杂志》
EI
CAS
CSCD
北大核心
2001年第6期420-421,共2页
Chinese Pharmaceutical Journal
