摘要
目的评价氨氯地平治疗老年高血压病的疗效和安全性并与依那普利比较。方法４６例老年高血压患者，采用随机单盲自身交叉法试验。氨氯地平组与依那普利组各有９例行动态血压监测。氨氯地平５～１０ｍｇ／ｄ，依那普利５～２０ｍｇ／ｄ，疗程４周。结果氨氯地平或依那普利治疗后，偶测血压比治疗前有显著降低，组间比较差异无显著性。动态血压显示氨氯地平控制２４ｈ血压明显较依那普利为优。不良反应的发生率氨氯地平较依那普利为少。结论氨氯地平是治疗老年高血压安全、有效的降压药物。
Aim To investigate the efficacy and safety of amlodipine. Methods 46 elderly hypertensive patients treated with amlodipine(n=46,5￣10 mg/d) and enalapril(n=46,5～20 mg/d) for 4 weeks. 9 cases were evaluated by 24 hour ambulatory blood pressure mornitoring. Results Clinical blood pressure(CBP) was significantly reduced by both drugs, while amlodipine was obviously better than enalapril in controlling 24 hour blood pressure. A lower incidence of adverse effects was observed in amlodipine group. Conclusion Amlodipine is a safe and effective antihypertensive agent in elderly essential bypertension.
出处
《高血压杂志》
CSCD
1998年第1期47-49,共3页
Chinese Journal of Hypertension
