摘要
观察苯那普利的降压效果及其对肾素血管紧张素系统和内皮素的影响。方法原发性高血压患者２２例予以口服苯那普利１０～２０ｍｇ／ｄ，治疗前及治疗４周后分别进行动态血压监测，同时应用放射免疫测定方法检测治疗前后血浆肾素活性、血管紧张素Ⅱ、醛固酮和内皮素水平，检验肝、肾功能，血糖等。结果苯那普利可以有效降低偶测血压和动态血压，降低血管紧张素Ⅱ和内皮素水平，而肾素活性升高，苯那普利还可以降低血糖，对肝肾功能无影响。结论苯那普利能够有效地降低血压，是一种有效、安全的降压药物。
Aim\ To investigate the antihypertensive efficacy of benazepril and its effects on the reninangiotensin system and endothelin.\ Methods\ 22 patients with essential hypertension were given benazepril 10～20 mg once daily.\ Ambulatory blood pressure monitoring(ABPM) were recorded before and after 4 weeks of the treatment with benazepril.\ The levels of plasme renin activity (PRA),angiotensin Ⅱ (Ang Ⅱ),aldosterin(Ald),and endothelin(ET) were measured with radioimmunoassay(RIA) before and after the management.\ Hepatic and renal function and blood sugar were also examined.\ Results\ Benazepril could lower both casual blood pressure(CBP) and ambulatory blood pressure(ABP) effectively.\ It could reduced the levels of AngⅡ and ET,while increased of PRA.\ It could reduced blood sugar without adverse effects on hepatic and renal function.\ Conclusion\ Benazepril lowers blood pressure effectively with few and mild adverse effect.
出处
《高血压杂志》
CSCD
1997年第4期305-307,共3页
Chinese Journal of Hypertension
关键词
苯那普利
高血压
内皮素
PRA
血管紧张素Ⅱ
benazepril
essential hypertension
reninangiotensin system
endothelin
