摘要
目的:探讨nm23-H1基因在甲状腺乳头状癌的表达及其与临床病理指标的关系。方法:采用免疫组化S-P法检测201例甲状腺乳头状癌,30例甲状腺良性增生及30例正常甲状腺组织中nm23-H1的表达情况。结果:(1)nm23-H1在甲状腺乳头状癌的表达阳性率为62.7％,明显低于两对照组(P<0.01或P<0.05)。(2)在甲状腺乳头状癌中,nm23-H1在Ⅰ型、Ⅱ型、Ⅲ型间及包膜内型、腺内型、腺外型间的表达均有显著性差异。(3)有淋巴结转移组nm23-H1的阳性率为54.5％,低于无淋巴结转移组(75.0％),其蛋白表达与颈淋巴结转移呈负相关。nm23-H1阴性表达的患者发生颈淋巴结转移的可能性大。结论:nm23-H1基因的表达与甲状腺乳头状癌的发生发展、浸润和颈淋巴结转移关系密切,检测mn23-H1可作为预测甲状腺乳头状癌颈淋巴,转移潜能的有价值的参考指标。
To evaluate the expression of nm23-Hl in papillary carcinoma and its clinical significance. Methods: The expression of nm23-Hl were determined with immunohistochemical technique in biopsy specimen of papillary thyroid carcinoma (PTC)(n =201),benign thyroid proliferation(BTP)(n =30) and normal control (NC)(n =30). Results: 1. The positive rate of nm23-Hl in PTC was 62.7 % and significantly lower than that in BTP and NC( P<0.01orP<0.05).2. The positive rate of nm23-Hl in PTC with lymph node metastasis was significantly lower than that without lymph node metastasis. 3. The expression of nm23-Hl in PTC was negatively correlated with lymph node metastasis (P<0.01). The patients with nm23-Hl negative expression had the high possibility of neck lymph node metastasis. Conclusion: The expression of nm23-H1 is correlated with carcinogenesis, progression, infiltration and neck lymph node metastasis of PTC, and it can serve as an important indicator for predicting lymph node metastasis of PTC.
出处
《天津医药》
CAS
北大核心
2001年第9期526-528,共3页
Tianjin Medical Journal
关键词
乳头状癌
甲状腺肿瘤
淋巴转移瘤
NM23-H1基因
genes, suppressor, tumor carcinoma, papillary thyroid neoplasms lymphatic metastasis
