摘要
目的 探讨乳腺癌组织中 nm2 3- H1及 ras基因的表达及其与淋巴结转移的关系。方法应用免疫组化方法检测 76例乳腺组织中 nm2 3- H1及 ras基因的表达情况 ,随访患者 5年生存率。结果 nm2 3- H1表达与乳腺癌组织分化及淋巴结转移负相关 ( P<0 .0 2 5 ,P<0 .0 5 ) ,nm2 3- H1及rasp2 1表达负相关 ( P<0 .0 5 ) ,nm2 3- H1阳性者较 rasp2 1阳性者五年生存率高 ( P<0 .0 1 )。结论 nm2 3- H1及 rasp2 1是评估乳腺肿瘤患者预后的良好指标 。
Objective To explore the expression of nm23 gene and ras gene and the correlation with lymph node metastasis.Methods By using SP immunohistochemical methods,the nm23 H 1 and rasp21 expression of 76 breast tissues were detected,and the 5 year survival rate were followed up.Results nm23 H 1 gene expression were negative correlation with histologic tumor grade and lymph node metastasis ( P<0.005,P<0.05 ) ,and its expression was negative correlation with rasp21 expression in breast cancers,the patients with nm23 H 1 gene expression had higher 5 year survival rate than those with rasp21 positive expression.Conclusion nm23 H 1 gene and rasp21 gene were good factor to value prognosis of the cases with breart,and it was ever more effective that both of them were combined.
出处
《肿瘤防治研究》
CAS
CSCD
2001年第5期354-355,共2页
Cancer Research on Prevention and Treatment
