摘要
目的 探讨结直肠癌增殖细胞核抗原表达与其预后因素之间的关系。方法 对 86例进展期结直肠癌患者的标本行免疫组化研究。根据增殖细胞核抗原表达的水平分析进展期结直肠癌术后的复发和生存。结果 结直肠癌增殖细胞核抗原表达与各种临床病理学因素有关。结论 当肿瘤分期增加时 ,增殖细胞核抗原标志指数增加 。
Objective To study the relationship between proliferating cell nuclear antigen expression and its prognostic factors in colorectal carcinoma.Methods Paraffin sections of 86 patients with advanced colorectal carcinoma was assessed by immunohistochemical study.Recurrence and survival of patients with advanced colorectal carcinoma after curative resection were analyzed in accordance with degree of PCNA expression.Results There were correlations between PCNA LI and various pathologic parameters.Conclusion PCNA LI increased significantly as the tumor stage advanced in colorectal carcinoma,the rates of recurrence and death got higher as PCNA LI increased after curative resection for colorectal carcinoma.
出处
《肿瘤防治研究》
CAS
CSCD
2001年第4期273-275,共3页
Cancer Research on Prevention and Treatment
关键词
结直肠癌
增殖细胞核抗原
病理学
结肠癌
直肠癌
预后
Colorectal carcinoma
Proliferating cell nuclear antigen expression
Malignancy
Pathologic factors
