摘要
目的研究白细胞介素6(interleukin-6,IL-6)与进展期结直肠癌低蛋白血症的关系。方法根据入院第二天用溴甲酚绿法(bromcresol green,BCG)测量空腹血白蛋白(Albumin,Alb)的浓度,将标本分为两组:低蛋白血症组(Alb<35g/L)及非低蛋白血症组(Alb≥35g/L),应用RT-PCR半定量的方法检测IL-6mRNA在低蛋白血症组以及非低蛋白血症组中的表达。结果IL-6mRNA在低蛋白血症组癌组织中的阳性表达率较非低蛋白血症组癌组织中的阳性高(P=0.000),在两组相应的正常黏膜组织标本中均不表达。结论IL-6通过影响机体对白蛋白的摄入、排出及代谢,在进展期结直肠癌低蛋白血症的发生、发展中起到重要作用。
Objective To study the relationship between the interleukin-6 and the advanced colorectal cancer associated with hypoalbuminaemia. Methods According to the concentration of empty stomach blood albumin（detected by BCG method at the second day in hospital） ,the patients were Divided into hypoalbu minaemia group （albumin〈 35 g/L ） and nonhypoalbuminaemia group （albumin≥35g/1 ）. RT-PCR semiquantity method was used to detect the expression of IL-6 mRNA in the two groups. Results The expression of IL-6 mRNA in hypoalbuminaemia group was significantly higher than that in nonhypoalbuminaemia group（ P =0. 000）, but was not expressed in the paired normal tissues of the both two groups. Conclusion It suggests that IL-6 plays an important role in the genesis and development of hypoalbuminaemia in patient with advanced colorectal cancer.
出处
《结直肠肛门外科》
2008年第1期2-5,共4页
Journal of Colorectal & Anal Surgery
基金
广西自然科学基金资助项目(桂科学2006-89)
广西卫生厅重点资助项目(桂卫重200523)2006-89)
