摘要
目的比较猴头菌固体发酵菌丝体醇提浸膏和水提浸膏甾醇类化合物成分的不同 ,探讨两者疗效差异的药化基础。方法皂化提取非皂化脂 ,利用薄层层析、反相HPLC对其中有关甾醇类物质进行检测。结果在醇提浸膏中检测到了较水提浸膏含量高的甾类物质 ,其中一种来自猴头菌菌丝体的甾醇类化合物 ,被初步鉴定为麦角甾醇。结论由于甾醇类化合物尤其麦角甾醇具有消炎、抗癌等多种生物学功能 ,所以麦角甾醇可能也是猴头菌的活性成分之一。醇提浸膏药效优于水提浸膏的原因可能与其含有较高量的脂类成分 ,特别是甾醇类物质有关。
PurposeThe aim is to compare the sterols in Hericium crinaceus ethanol extract and water extract from solid fermented hyphae and to study the pharmaceutical chemical basis of the different medicinal effects. MethodsThe nonsaponifiable lipids were isolated by saponification.The sterols were then detected by TLC and RP-HPLC.ResultsThe content of sterols in ethanol extract was found to be higher than that in water extract.And one type of sterols from Hericium erinaceus hyphae was identified as ergosterol.ConclusionDue to ergosterol′s multifunction in biological activities,it may well be one of the active components of hyphae.And higher content of lipids, especially sterols may be one of the reasons for the better medicinal effect of ethanol extract than water extract.
出处
《中国生化药物杂志》
CAS
CSCD
2001年第3期124-126,共3页
Chinese Journal of Biochemical Pharmaceutics
关键词
猴头菌
滑膏
非皂化脂
麦角甾醇
中药
Hericium erinaceus
Extract
Nonsaponifiable lipids
Ergosterol
