摘要
目的 回顾性分析胶质瘤患者术后放射治疗的疗效 ,探讨影响放射治疗胶质瘤预后的因素。方法 对资料完整的 16 4例胶质瘤患者进行回顾性研究。其中低分级胶质瘤 79例 ,高分级胶质瘤 47例 ,室管膜细胞瘤 2 4例 ,少突胶质细胞瘤 14例。手术全切 71例 ,次全切 86例 ,单纯活检 7例。术后 2周至 1个月内接受放射治疗 ,其中 135例采用60 Coγ射线 ,2 9例采用加速器光子线和电子线混合线束。寿命表法计算生存率 ,Cox比例风险模型进行预后的多因素分析。结果 低分级胶质瘤的 1、3、5年生存率分别为 91%、89%、82 % ;高分级胶质瘤的 1、3、5年生存率分别为 5 3%、40 %、36 %。年龄 <40岁、低分级胶质瘤、手术全切肿瘤的患者预后较好。结论 年龄、病理分级。
Objective A retrospective analysis was carried out to evaluate the results of glioma treated by postoperative radiotherapy and the prognostic factors. Methods 164 evaluable glioma patients were studied retrospectively. Of these, 79 had low grade , 47 had high grade gliomas, 24 had ependymal gliomas , and 14 had oligodendroglioma.Seventy one patients received grossly total resection, 86 had subtotal resection, whereas 7 were biopsied only. External beam radiotherapy started within 2 weeks to 1 month after the surgery. 135 patients received Colbalt γ ray beam, and 29 received mixed photon and electron beam from the linear accelerator. The cumulative survival rate and influencing factors were analyzed and compared by the life table method and Cox proportional hazard model. Results The 1 , 3 , and 5 year cumulative survival rates of patients with low grade gliomas were 91%, 89%, 82%, as compared with 53%, 40%, 36% for those patients with high grade gliomas. Univariate analysis showed that patients with age<40, low grade glioma, grossly total tumor resection gave better survivals. Conclusion Tumor histology, patient's age and extent of resection are related to survival.
出处
《中华放射肿瘤学杂志》
CSCD
北大核心
2001年第2期108-111,共4页
Chinese Journal of Radiation Oncology
