期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

儿茶酚胺氧位甲基转移酶基因多态性研究 被引量：5

Catechol-O-methyltransferase Gene Polymorphisms in Chinese Han Nationality
在线阅读 下载PDF
导出
摘要 为分析中国汉族人儿茶酚胺氧位甲基转移酶 (COMT)基因多态性 ,用聚合酶链反应 限制性片段长度多态性 (PCR RFLP)技术分析了 53名正常中国汉族人COMT基因 1 94 7位点的多态性 ;并对NIaⅢ内切酶酶切后有异常带出现的标本PCR产物直接进行序列分析。发现中国汉族人COMT基因的A 1 94 7位点的频率为 0 .2 8;基因型G/G、G/A与A/A的频率分别为 0 .51 ,0 .4 2和 0 .0 7;并发现了C1 883/G和G1 966/T The polymorphism of G/A 1947 in exon 4 of COMT gene was analyzed in a population of 53 randomly selected Chinese individuals by polymerase chain reaction restriction fragment length polymorphism (PCR RFLP). The frequency of A allele was 0.28. The index of homozygous G/G、G/A and A/A were 0.51, 0.42 and 0.07 respectively. The C1883/G and G1966/T polymorphism were found in a Chinese by genetic analyzer technique.
作者 高清玲 邵明 李勇杰 陈彪
机构地区 首都医科大学宣武医院北京功能神经外科研究所
出处 《首都医科大学学报》 CAS 2001年第2期113-115,共3页 Journal of Capital Medical University
基金 北京市自然科学基金重点项目!(79810 0 1) 北京市科技新星计划资助项目!(95 4812 6 0 0 ) 北京市卫生局重点学科课题资助项目
关键词 儿茶酚胺氧位甲基转移酶 基因多态性 聚合酶链反应 catechol O methyltransferase gene polymorphism polymerase chain reaction
分类号 Q786 [生物学—分子生物学]
  • 相关文献

参考文献8

  • 1[1]Axelrod J, Tomchick R. Enzymatic O-methylation of epinephrine and other catechols. J Biol Chem, 1958,233:702～705
  • 2[2]Grossman M H, Littrell J B, Weinatein R. Identification of the possible molecular basis for inheri-ted differences in human catechol-O-methyltransferase. Soc Neurosci, 1992,18:70
  • 3[3]Lundstrom K, Tenhunen J, Tilgmann C, et al. Cloning, expression and structure of catechol-O-methyltransferase. Biochem Biophys Acta, 1995,1251:1～10
  • 4[4]Spielman R S, Weinshilboum R M. Genetics of red cell COMT activity: Analysis of thermal stability and family data. Am J Med Genet, 1981,10:279～290
  • 5[5]Lotta T, Vidgren J, Tilgmann C. Kinnetic of human soluble and membrane-bound catechol-O-methyltransferase: A revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry, 1995,34:4202～4210
  • 6[6]Barnea E R, Maclusky N J, Decherney A H, et al. Catechol-O-methyltransferase activity in the human term placenta. Am J Perinatol, 1988,5:121～127
  • 7[7]Reilly D K, Rivera-Calimlim L, VanDyke D. Catechol-O-methyltransferase activity: A determinant of levodopa response. Clin Pharmacol Ther, 1980,28:278～268
  • 8[8]Hoda F, Nicholl D, Bennett P, et al. No association between Parkinson′s disease and low-activity alleles of catechol O-methyltransferase. Biochem Biophys Res Commun, 1996,228(3):780～784

同被引文献49

  • 1张明园.精神科量表评定手册 [M].长沙：湖南科学技术出版社,1998.17- 27.
  • 2Tardiff K. The risk of assaultive behaviour in suicidal patients. Acta Psychiatr Scand, 1981,64 : 295-300.
  • 3Virkkunen M, de Jong J, Bartko J, et al. Psychobiological concomitants of history of suicide attempts among violent offenders and impulsive fire setters. Arch Gen Psychiatry, 1989,46 : 604-606.
  • 4Multlsite intervention study on suicide behavlours-SUPRE-MISS:components and instruments. WHO, Geneva 2000. http//www.who. int/mental-health/PDF documents/ SUPRE- MISS. pdf.
  • 5Napolitano A, Cesura AM, Da Prada M. The role of monoamine oxidase and cat echol-O methyltransferase in dopaminergic neurotransmission. J Neural Transm Suppl, 1995,45 : 35-45.
  • 6Lachman HM, Morrow B, Shprintzen R, et ah Association of codon 108/158 catechol-O-methyltransferase gene polymorphism with the psychiatric manifestations of velo cardio-facial syndrome.An: J Med Genet, 1996,67 : 468-472.
  • 7Gogos JA, Morgan M, Luine V, et ah Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior. Proc Natl Acad Sc, 1998,95 :9991-9996.
  • 8Hailer J, Makara GB, Kruk MR. Catecholaminergic involvement in the control of aggression: hormones, the periphrel sympathetic, and central noradrenergic systems. Neurosci Biobehav Rev, 1998, 22 :85-97.
  • 9Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res,1988,16: 1215.
  • 10Kunugi H, Nanko S, Ueki A, et al. High and low activity alleles of catechol O-methyltransferase gene: ethnic difference and possible association with Parkinson' s disease. Neurosci Lett, 1997,221 (23) : 202-204.

引证文献5

二级引证文献11

首都医科大学学报
2001年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部