摘要
目的了解农药自杀未遂者流行特征以及环境因素与儿茶酚胺氧位甲基转移酶(COMT)基因多态性的关系,为该人群自杀行为的预防提供科学依据。方法对从2003年1至12月在综合医院收集到的农药自杀未遂者107例,分别调查其相关影响因素和收集1ml全血进行COMT基因多态性分析。结果107例中,男女之比为1∶1.55;年龄13～81岁,主要集中在20～44岁(67.3%);文化程度以小学及以下为主(59.8%);有精神障碍史者13例(12.1%)。一年内有情感冲突者84例(78.5%)。有自杀冲动性者30例(28.0%)。一级亲属中有过自杀行为者5例。多因素分析显示:精神障碍、自杀未遂冲动性与COMT基因间存在相互作用,其关联强度值分别为0.052(95%CI:0.006～0.437)、2.917(95%CI:1.097～7.760)。结论在该人群中,尤其应重视年轻女性,有精神障碍、一年内有情感冲突者。COMT基因存在遗传异质性,且与精神障碍、自杀冲动具有相互作用。
Objective To understand the association between gene polymorphism of catechol-O- methyltransferase （COMT） and suicide attempters taking pesticides orally and to provide a scientific base for the prevention of suicidal behavior. Methods 107 suicide attempters taking pesticides orally were collected from The People＇s Hospitals in Shandong Province from January 2003 through December 2003. The informations of all the attempters were obtained and 1 ml whole blood from of them were collected. Molecular biological techniques were used to study the gene type of each subject. Results In the 107 suicide attempters, the ratio of male to female is 1 ： 1.55 ; 67.3 % of them were in age range of 20-44 years; 59. 8% of them had education level of elementary school or lower. 13 suicide attempters （ 12. 1% of all the attempters） had psychiatric disorders. 84 suicide attempters （78.5% of all the attempters） had affective conflicts with others in the recent year. 30 suicide attempters （28.0% of the suicide attempters ） had impulsive behavior. Multivariate logistic regression model analysis showed that suicide impulsion and psychiatric disorders were significantly associated with COMT Val/Val, their OR values were 0. 052 （95% CI： 0.006-0.437）, 2.917 （95% CI： 1.097-7.760）. Conclusion In this population, more attention should be paid to young female people with psychiatric disorders or having affective conflicts with others in the recent year so as to prevent suicide, This study supported that there is heterogeneity in COMT gene in suicide attempters and there is interaction between COMT Val/Val and suicide impulsion and psychiatric disorders.
出处
《中华内科杂志》
CAS
CSCD
北大核心
2006年第5期403-405,共3页
Chinese Journal of Internal Medicine
基金
山东省自然科学基金资助项目(21320005200262)
