摘要
为探讨C -反应蛋白与动脉粥样硬化及其它心血管病危险因素的关系 ,以高分辨率B型超声法测定91例受检者的颈动脉内膜 -中膜厚度 ,作为动脉粥样硬化的指标 ;以生物化学方法测定血清C -反应蛋白、血脂水平和血浆凝血纤溶活性。结果发现 ,颈动脉内膜 -中膜厚度≥ 0 .8mm组的血清C -反应蛋白水平高于内膜 -中膜厚度 <0 .8mm组 (4 .4± 4.3mg L比 2 .7± 1.3mg L) ,但差异的显著性无统计学意义 (P =0 .0 71)。 6例血清C -反应蛋白水平≥ 8.0mg L者颈动脉内膜 -中膜厚度明显高于其余 85例血清C -反应蛋白 <8.0mg L者 (1.0 33± 0 .2 94mm比 0 .812± 0 .2 2 2mm ,P <0 .0 5 )。多因素逐步回归分析显示血清C -反应蛋白水平与血清甘油三酯水平 (β=0 .5 33,P =0 .0 0 2 ) ,及血浆凝血因子VII (β =0 .40 6 ,P =0 .0 17)和纤溶酶原激活物抑制剂 - 1(β =0 .312 ,P =0 .0 5 )活性呈显著正相关。因此 ,C -反应蛋白作为某些炎症的反应蛋白 ,与颈动脉内膜 -中膜厚度及其某些心血管病危险因素有关 ,提示炎症因素可能在动脉粥样硬化发病中起作用。
Aim To investigate the association of C reactive protein (CRP) with carotid intima media thickness and some risk factors of cardiovascular disease. Methods Carotid IMT was measured by high resolution B mode ultrasound, and blood levels of CRP, lipids, clotting factors and fibrinolytic parameters were determined by relevant biochemical assay in 91 subjects. Results The difference in level of CRP between subjects with carotid IMT≥0.8 mm and those with IMT <0.8 mm was not significant (4.4±4.3 mg/L vs 2.7±1.3 mg/L, P=0.07), while the IMT was significantly higher in 6 subjects with CRP≥8.0 mg/L than those with CRP<8.0 mg/L (1.033±0.294 mm vs 0.812±0.222 mm, P<0.05). The level of CRP was positively correlated with triglyceride level, activities of coagulating factor VII and plasminogen activator inhibitor type 1 on multiple stepwise regression analysis. Conclusion Higher level of CRP, the reactant of inflammation, may account for the role of inflammation in the pathogenesis of atherosclerosis.
出处
《中国动脉硬化杂志》
CAS
CSCD
2001年第2期146-148,共3页
Chinese Journal of Arteriosclerosis
