摘要
目的和方法：观察颈动脉内膜中膜厚度（ＩＭＴ）与心血管疾病危险因素的关系以及凝血纤溶活性对颈动脉ＩＭＴ的影响。采用高频率Ｂ型超声法测定１６０例中老年人的颈动脉ＩＭＴ，并与冠心病的多种危险因素和凝血纤溶系统的多项指标进行对比分析。结果：，颈动脉ＩＭＴ≥０．８ｍｍ组的冠心病、脑血管病、高血压病的发生率明显高于ＩＭＴ＜０．８ｍｍ组，年龄、收缩压、总胆固醇、低密度脂蛋白胆固醇（ＬＤＬＣ）及组织型纤溶酶原激活剂水平也明显高于ＩＭＴ＜０．８ｍｍ组。多因素逐步回归分析显示，ＬＤＬＣ、高血压和年龄是颈动脉ＩＭＴ增加的独立危险因素。结论：颈动脉的ＩＭＴ增加作为颈动脉粥样硬化的早期征象，与冠状动脉和脑动脉硬化有相似的病理基础。
Aim and Methods:To investigate the association of carotid arterial intima media thickness (IMT) with risk factors of cardiocasular disease, and the influence of hemostatic factors and fibrinolytic activity on carotid IMT. Carotid IMT was measured by high resolution B mode ultrasound in 160 subjects aged 45 77 years. The association of carotid IMT with classical cardiovascular risk factors was assessed.Thereafter, the effect of hemostatic and fibrinolytic activities on carotid IMT was evaluated. Results:In subjects with IMT >0.8 mm, the prevalence of coronary heart disease, cerebrovascular disease, hypertension was significantly higher,and the aging, and the level of systolic blood pressure, total and LDL cholesterol, tissue type plasminogen activator were also significantly higher when compared with those in subjects with IMT <0. 8mm. Age, hypertension and LDL C were shown as the independent determinants of carotid IMT on logistic regression analysis. Conclusion:The pathogenesis of atherosclerosis between carotid and coronary or cerebral arteries is the similar. Correction of cardiovascular risk factors may prevent or delay the progress of carotid atherosclerosis.
出处
《中国应用生理学杂志》
CAS
CSCD
1999年第1期22-25,共4页
Chinese Journal of Applied Physiology
