摘要
目的 研究儿童与成人正畸过程中龈沟液生化成分含量的变化 ,分析儿童与成人牙齿移动速度存在差异的原因。方法 对样本 84例 (儿童组 43例 ,成人组 41例 )采用放射免疫测试法 ,测定其上颌侧切牙受唇向倾斜力 2 4h前后龈沟液中前列腺素E2 (prostaglandinE2 ,PGE2 )、白细胞介素 6(interleukin 6 ,IL 6 )和粒 巨噬细胞集落刺激因子 (granulocyte macrophagecolonystimulatingfactor,GM CSF)总量和浓度的变化 ,讨论其变化规律及两个年龄组变化的差异。结果 正畸加力 2 4h前后两组GCF PGE2 总量和浓度均明显增加 (P <0 0 1) ,对照侧均无变化 (P >0 0 5 ) ;两组GCF IL 6总量明显增加(P <0 0 1) ,浓度只有儿童组增加 (P <0 0 1) ;两组GCF GM CSF总量明显增加 (P <0 0 1) ,浓度只有儿童组增加 (P <0 0 1)。结论 正畸牙齿移动过程中龈沟液生化成分的变化在儿童与成人间存在差异。
Objective To study the changes of biochemical components in GCF between children and adults during orthodontic tooth movement Methods 84 patients (child group: 43 subjects, adult group: 41 subjects) were included, each having one treatment tooth and one contralateral control tooth The levels of PGE 2, IL 6 and GM CSF in GCF of upper lateral incisor were investigated before activation and at 24 th hour after the applying of labial orthodontic force, by using of highly sensitive radioimmunoassay Results PGE 2, IL 6 and GM CSF were highly detectable in GCF (>90%) At experimental sides, total amount of GCF PGE 2, IL 6 and GM CSF levels was significantly elevated at 24 th hour compared with that before activation in both child group and adult group Mean concentration of PGE 2 in GCF increased significantly at 24 th hour in the two groups, while that of IL 6 and GM CSF did only in child group The levels of PGE 2, IL 6 and GM CSF in GCF remained at baseline throughout the study for the control teeth Conclusion There were some differences of GCF cytokine changes between child and adult groups
出处
《中华口腔医学杂志》
CAS
CSCD
北大核心
2001年第3期219-221,共3页
Chinese Journal of Stomatology
基金
2 11工程和卫生部优秀青年科技人才专项科研基金资助项目 ( 96 Q 0 5 5 )
