摘要
Toll信号转导通路在果蝇的发育和天然免疫反应中起重要作用 .最近在小鼠进行的定点克隆研究表明Lps位座编码一种Toll样受体TLR4,该受体作为LPS受体复合物的跨膜成分而转导脂多糖 (LPS)信号 ,而其相关蛋白TLR2则在其他病原体微生物介导的细胞反应中起作用 .TLR4的发现使我们对LPS信号转导通路的认识前进了一大步 .
Toll signal transduction pathway plays a critical role in development as well as in innate immune responses in Drosophila. Positional cloning work proceeded in mice recently has revealed that Lps encodes the Toll-like receptor 4 (TLR4) of mammals, which functions as the transmembrane component of LPS receptor complex. In contrast, TLR2, a receptor closely related to TLR4, makes no contribution to LPS induced signaling. The discovery of TLR4 has greatly promoted understanding on the LPS signal transduction pathway.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2001年第3期299-303,共5页
Progress In Biochemistry and Biophysics
基金
国家杰出青年科学基金 (3992 50 1 4 )
国家自然科学基金重点项目 (39830 4 0 0 )
军队杰出人才基金(98J0 0 3)资助项目&&
