摘要
通过对１０５２例肝炎肝组织的ＨＥ、组织化学及免疫组织化学染色观察，发现其肝内血管有炎症、破坏、增生及阻塞四种病变，并制定了评级标准。结果表明：①急、慢性肝炎皆有血管炎症、破坏及阻塞病变，其随肝病变加重而上升（Ｐ＜０．００１）；②血管增生可导致弹力纤维及ＦＮ增多而引起肝硬化；③ＡＳＨ、ＳＳＨ及ＣＳＨ肝内血管明显破坏及阻塞而导致肝梗塞，预后不良。这些发现为肝炎病理机制的研究提供了形态学依据。
he morphological changes in hepatic blood vessels of 1052
patients with viral hepatitis have been strdied by HE.hisochemistry
and immunohistochemistry stain .There are four types of lesions in
he-patic blood vessels of inflammation, damage, proliferation and
occlusion,and sinus dilation or sludge.The inflammation, damage,and
occlusion of the blood vessels are commonly seen in both acute and
chronic he patitis, which are in accordandce with hepatic
pathological changes(P<0.001).Proliferation of the blood vessels can
cause the aggregation of collagen,elastic fibril and fibronectin,
which led to hepatic cirrhosis.Occlusion of the(interlobular) vessels
causing local(or multi-)infarctions is the typi-cal presentation in
ASH, SSH,and CSH. Lesions of blood vessels and sinus could impair the
supply of oxygen and nutrition liver cells which led to necrosis,
degeneration, swelling of the parenchymal cells. All of these results
might be helpful to the reseach of pathogenesis of viral hepatitis.
出处
《肝脏病杂志》
CSCD
1995年第3期155-157,共3页
