摘要
利用 Captive bubble水相接触角技术对一系列负载生物活性功能基的聚醚氨酯溶液成膜后进行静态水相接触角研究 ,得到了材料 -水界面自由能γSW及其非极性部分γd SV和极性部分γpSV的贡献 .结果表明 ,对于负载不同生物功能基的聚醚氨酯 ,材料表面的水相静态接触角 θ以及 γSW、γd SV、γp SV与材料中 PEO含量有关 .对磺化 PEU,随材料本体和表面 PEO含量升高 ,γSW升高 .磺化 PEU的侧链末端分别接有 Lys或 Tyr可使γSW下降 .采用血小板粘附实验和凝血时间实验对合成的生物功能化抗凝血材料聚氨酯材料进行了初步的血液相容性研究 .结果表明 ,材料抗凝血能力与改性表面的表面能密切相关 ,负载生物活性功能基的聚醚氨酯具有预期的优良血液相容性 。
A series of biomolecular modified polyurethane were prepared. PEU- g -PEO-SO 3Na, PEU- g -PEO-C 18 , PEU- g -PEO-SO 2Lys, PEU- g -PEO-SO 2Tyr, their surface properties were investigated by contact angle measurement. The polymer-water interface free energy γ SW , the contribution of its polarity γ p SV and its non-polarity γ d SV were obtained by using captive bubble method. The results indicate that in the sulfonate modified PEU surface, the value of γ SW increased with the content of PEO. When Lys or Tyr was grafted on the end of sulfonate PEU side chain, γ SW decreased. The blood compatibility of the biomolecular modified polyurethanes was determined by measurements of platelet adhesion, plasma recalcification time(RTT) and prothrombin time(PTT). All biomolecular modified polyurethanes show good blood compatibility and potential in coating materials in blood contact device.
出处
《应用化学》
CAS
CSCD
北大核心
2001年第5期384-388,共5页
Chinese Journal of Applied Chemistry
基金
国家自然科学基金资助项目! (2 980 40 0 9)
