摘要
作者用半乳糖经乙酰化、溴代、缩合、置换及加成反应制得2-亚氨基-2-甲氧基乙基-1-硫代-β-D-半乳吡喃糖苷,最后与人血清白蛋白偶连后得不同糖密度的半乳糖基新糖白蛋白(NGA),并用^(90)mTc标记后进行了动物及临床试验。结果^(99m)Tc-NGA-21的肝最大摄取率为82.6％,肝显像清晰。
Galactosyl-neoglycoalbumin(NGA) can bind with the asialoglycopro-teins receptor specifically on the surfaceof mammal's liver We prepared NGA indifferent carbohydrate density and madesome animal and clinical tests with tech-netium-99m labeled NGA. The maximumabsorptance of ^(99m)Tc-NGA-21 was 82.6%in liver. We also got the satisfactory ra-diograps of live. NGA was synthesized by the covalentcoupling of a carbohydrate bifunctionalreagent, 2-imino-2-methoxyethyl-1-thio-galactose (4), to human serum al-bumin The cyanomethyl-1-thio-glycosideof β-D-galactose (3) was Prepared fromthe pseudothiourea derivative (2) whichwas synthesized by acetylation, bromina-tion and substitution of galactose. (8)could be converted to (4) by treatmentwith sodium methoxide
出处
《华西医科大学学报》
CAS
CSCD
1991年第4期368-371,共4页
Journal of West China University of Medical Sciences
关键词
苷
白蛋白
糖密度
NGA
核素显像
Galactosyl-neoglycoalbumin
Asialoglycoproteins receptor
IME-thiogalactose
Hepatic binding protein
Carbohydrate density
Hepatic cell membranes
Rediography
