摘要
报道了以半乳糖为原料制得２－亚氨基－２－甲氧乙基－１－硫代－β－Ｄ－半乳吡喃糖苷，再与药用明胶偶联制得半乳糖基明胶（ｇａｌａｃｔｏｓｙｌｇｅｌａｔｉｎ，ＧＧ）的方法，并用９９ｍＴｃ标记后进行了动物肝显像及体内分布试验，结果表明，９９ｍＴｃ－ＧＧ主要集中于肝脏，肝显像清晰，有可能作为一种新的肝受体显像剂。
Galactosyl gelatin (GG) was synthesized by the covalent coupling of a carbohydrate bifunctional reagent, 2imino2methoxyethyl1thiogalactose, to medical gelatin. Animal tests of radiograph in rabbit and the tissue radioactivity distribution in mice with,7 99m Tc labeled GG showed that 99mTcGG can be concentrated specifically in liver, and is possible to be used as a hepatic radiography reagent.
出处
《华西药学杂志》
CAS
CSCD
北大核心
1999年第3期154-156,共3页
West China Journal of Pharmaceutical Sciences
关键词
肝显像剂
半乳糖基明胶
制备
放射性核素显像
Asialoglycoprotein receptorGalactosylneoglycoalbuminGalactosyl GelatinCarbohydrate densityRadiographyHepatic receptor radiography
