摘要
目的 :对不同临床分期慢性肺原性心脏病病人血浆内皮素 - 1 ( ET- 1 )及降钙素基因相关肽 ( CGRP)进行检测。方法 :采用放射免疫法对标本进行测定 ,以呼吸系统急性感染病人作为照。结果 :代偿期肺原性心脏病病人血浆 ET- 1水平显著高于对照组 ( P<0 .0 1 ) ,而 CGRP水平无差异 ;失代偿期病人 ET- 1水平显著高于代偿期病人 ( P<0 .0 5 ) ,CGRP水平无差异 ;失代偿期病人 ET- 1水平显著高于代偿期病人 ( P<0 .0 5 ) ,CGRP水平则显著低于代偿期病人 ( P<0 .0 1 )。结论 :ET- 1及 CGRP在慢性阻塞性疾病的发生和发展过程中起一定作用 ,且与疾病的严重程度相关。
Objective:to determine the levels of endothelin 1(ET 1) and calcitonin generelative peptide(CGRP) in plasma of patients with chronic pulmonary heart disease in different clinic stages.Method:Radio immunoassay was used to determine samples,and the patients with pulmonary infection were taken as controls.Results:The ET 1 level of patients with pulmonary heart disease in compensatory period was higher than that of control group ( P <0 01),and the CGRP level was not different.The ET 1 level of the patiens in decompensatory period was higher than that of the ones in compensatory period( P <0 05),but the CGRP level was obviously reversed( P <0 01).Conclusion:ET 1 and CGRP have a role in the process of occurance and development of chronic obstructive disease of lung and their levels are relate to the severity of diseare.
出处
《滨州医学院学报》
2000年第1期16-17,共2页
Journal of Binzhou Medical University
