摘要
本实验利用四氯化碳诱发小白鼠急性肝损伤模型，通过测定肝组织及血清SOD、GSH-Px和MDA、观察川芎嗪对肝损伤的保护计用。结果表明，川芎嗪能显著提高肝血清SODGSH－Px活性，减少MDA生成量（P＜0．01）．说明川芎嗪有一定程度抗自由基与抗脂质过氧化作用，对四氯化碳肝损伤有显著的保护作用。
Objective: To observe the protective effects of ligustrazini on liver injury Methods: by use of the model of acute liver damage induced by CCl4, and by determining the superoxide dismutase (SOD),glutathione peroxidase (GSH-Px), and malondialdehyde (MDA) in the serum and liver tissue. ReSults: The results showed that compared with control group, Ligustrazini evidently increased the activities of SOD and GSH-Px and decreased the production of MDA (P<0.01) in the liver tissue and serum.
出处
《黑龙江医药科学》
2000年第3期3-4,共2页
Heilongjiang Medicine and Pharmacy
关键词
四氯化碳
肝损伤
川芎嗪
超氧化物歧化酶
谷胱甘肽过氧化物酶
中药
丙二醛
药理
All these suggest that ligustrazini has the effects of anti-free radical and anti-lipid peroxidetion in certain degree, and has the protective effects on the liver from damage induced by CCl_4
