摘要
目的 探讨中药眼底Ⅰ号方治疗视网膜静脉阻塞的作用机理。方法 以脉络宁注射液为对照 ,观察眼底Ⅰ号方对小鼠耳廓微循环以及由肾上腺素诱导的血瘀模型大鼠的血小板聚集率和血液流变学参数的影响。结果 对小鼠耳廓血管血液速度的测定与生理盐水对照组相比显示 ,眼底 1号方组的小鼠耳廓血流速度明显增快 ,血管扩张 ,动静脉口径比值减小 ;大鼠血小板聚集作用受到明显抑制 ,全血粘度及血浆粘度降低 ,差异有显著性。结论 眼底Ⅰ号方能抑制血瘀模型大鼠的血小板聚集率 ,改善血液流变参数 ,并能增加小鼠耳廓血流速度。
OBJECTIVE To observe the functional mechanism of traditional Chinese medicine yandiyihaofang (眼底Ⅰ号方) in treatment of retinal vein occlusion METHODS Compared with the mailuoning(脉络宁) injection, effect of yandiyihaofang on auricle microcirculation in the small mice was observed Platelet aggregation ratio and parameter of blood rheology were determined in the big mices with experimental blood occlusion induced with adrenalin RESULTS The blood flow rate was obviously accelerated in auricle blood vessel of rats treated with yandiyihaofang compared with control group, and the blood vessel was dilated, and ratio of artery and vein in diameter was reduced Platelet aggregation was inhibited; whole blood viscosity and blood plasma viscosity were reduced The difference was significant between the treated group and the control group CONCLUSIONS Yandiyihaofang could inhibit platelet aggregation ratio in mice with experimental blood occlusion, and could improve parameter of blood rheology and enhance speed of blood flow in auricle microcirculation of the small mice
出处
《中国中医眼科杂志》
2001年第2期69-71,共3页
China Journal of Chinese Ophthalmology
基金
江苏省教委自然科学基金资助项目! (JW970 0 90 )
