摘要
目的 :研究MT在乳腺癌中的表达 ,探讨其预后价值。方法 :采用免疫组化S -P法 ,检测 91例乳腺癌中MT的表达。结果 :a .MT表达与肿瘤大小、病理分型、组织学分级、局部复发、远处转移相关 (P <0 0 5 ) ,而与年龄、淋巴结转移无关 (P >0 0 5 )。b .单因素分析结果表明肿瘤大小、淋巴结状态、组织学分级 ,MT都有预后意义 ,其中肿瘤大小 ,淋巴结状态 ,MT具有独立预后价值。c.MT阳性表达者生存期短。结论 :MT有可能作为判断乳腺癌预后的生物学指标之一。
Objective:To study the expression of metallothionein (MT) and determine their relationship with clinicopathological feature and prognosis in human breast carcinoma. Methods:Immurohistochemical technique, S-P method was used. Results:a. The expression of MT was associated with tumour size, pathological type, histological grade, local recurrence, distant metastasis(P<0 05), there was no relation between the expression of MT and ages, lymphnode metastasis(P>0 05). b.The result of logistical regression analysis showed that tumor size, lymphnode status, MT independent prognostic factors. c.Patients with positive MT lived shorter than those of negative. Conclusion:The findings suggested that the expression of MT may be a useful marker for predicting the prognosis of breast carcinoma.
出处
《内蒙古医学院学报》
2001年第1期1-4,共4页
Acta Academiae Medicinae Neimongol
