摘要
SJAMP对由注射大肠杆菌诱发的家兔急性广泛性血管内凝血(DIC)无明显治疗效果,但在体内外均有明显的抗凝作用,在体内作用不持久,在体外对富含血小板血浆的抗凝作用随温育时间延长有减弱的倾向。这可能与其聚集血小板、暴露其膜上的凝血活性有关。
With a rabbit model of acute disseminated intravascular coagulation induced by injection of E. Coli. no evident experimental therapeutic effect of SJAMP on that model was observed. Experiments showed that SJAMP possesed obvious anticoagulant activity in vivo which only persisted a relatively shorttime. When SJAMP was co-incubated with platlet rich plasma in vitro,the anticoagulant activity gradually became weaker during the period of incubation and that may be related with SJAMP induced platlet aggregation and the expression of procoagulant activity on platlet membrane.
出处
《湖南中医学院学报》
1991年第3期37-39,共3页
Journal of Hunan College of Traditional Chinese Medicine
关键词
刺参
酸性粘多糖
DIC
抗凝活性
dipsacaceae/pharmacology
@SJAMP
disseminated intravascular coagulation/drug therapy
disseminated intravascular coagulation/pathology
blood platelest
