摘要
目的 :检测ER、C erbB 2、PCNA的表达与乳腺浸润性导管癌临床和病理特征的关系 ,并探讨其作为预后指标的可行性。方法 :采用LSAB法对 6 0例乳腺浸润性导管癌术后根治标本 ,作ER、C erbB 2、PCNA的免疫组化研究。结果 :(1)ER阳性率随着乳腺癌组织学分级的升高而降低 ,ER阳性率在Ⅰ级 (16 / 2 0 )和Ⅲ级 (7/ 19)差异有显著性 (P <0 .0 5 ) ,Ⅰ级 (16 / 2 0 )和Ⅱ级 (13/ 2 1) ,Ⅱ级 (13/ 2 1)和Ⅲ级 (7/ 19)差异无显著性 (P >0 .0 5 ) ;ER在腋窝淋巴结无转移的病例中表达率较高。 (2 )C erbB 2的表达与腋窝淋巴结转移呈正相关 (P <0 .0 5 ) ,与肿瘤的大小及组织学分级无关。 (3)PCNA与组织学分级、腋窝淋巴结转移呈正相关 (P <0 .0 5 ) ,与肿瘤的大小无关。 (4)C erbB 2的表达与PCNA呈正相关 ,与ER呈负相关。结论 :乳腺浸润性导管癌患者ER过度表达者预后好 ,C erbB 2、PCNA过度表达者预后不良 ,三者联合检测可作为判断乳腺浸润性导管癌患者预后的有效指标。
Objective:To study the relationship between the expression of ER,C erbB 2,PCNA and the clinicopathological characteristics in invasive ductal cacinoma of the breast and to evaluate the possibility to use them as prognostic predictors. Method Using LSAB immunohistochemical method,ER,C erbB 2 and PCNA expression in 60 cases of invasive ductal carcinoma were detected .Results (1)The positive rate of ER was 80%(16/20)in gradeⅠ,61.90%(13/21)in gradeⅡ and 36.84%(7/19) in grade Ⅲ of the carcinoma. There was no statistically significant difference between gradeⅠand gradeⅡ as well as gradeⅡand grade Ⅲ( P >0.05), but there was statistically significant difference between gradeⅠand grade Ⅲ( P <0.005).The negative relationship was shown between the positive rate of ER and histologic grade and axillary lymph node metastasis .(2) The expression of C erbB 2 was shown to be positively related to axillary lymph node metastasis ,while there was no apparent relationship between the expression of C erbB 2 and the size and the histologic grade of the tumor. (3)There was a positive relationship between the expression of PCNA and the histologic grade and axillary lymph node metastasis ,but no apparent relationship was found between the expression of PCNA and the tumor size.(4) The expression of C erbB 2 was positively correlated to PCNA but negatively correlated to ER. Conclusion ER over expression indicates a good prognosis but C erbB 2 and PCNA over expression indicate a bad prognosis in patients with invasive ductal carcinoma of the breast
出处
《广州医学院学报》
2001年第1期13-15,共3页
Academic Journal of Guangzhou Medical College
