摘要
采用肾血管性高血压大鼠（两肾一夹）（简称ＲＨＲ），分别以１２．５、２５、５０ｍｇ·ｋｇ～－１预防口服给药５周，每日１次，观察海洋硫酸多糖 ＡＨＤ的降压作用及对 ＲＨＲ血清一氧化氮（ＮＯ）、血浆内皮素（ＥＴ）和血管紧张素Ⅱ（ＡｎｇⅡ）含量的影响。结果表明：ＡＨＤ明显降低ＲＨＲ大鼠的收缩压和舒张压，降压强度在给药剂量范围内是剂量依赖性；显著增加血清ＮＯ含量；明显降低血浆ＥＴ、ＡｎｇⅡ含量。揭示ＡＨＲ对ＲＨＲ具有良好的降压作用，可能与促进体内 ＮＯ生成，降低ＥＴ和 ＡｎｇⅡ释放有关。
The antihypertensive effect of marine sulfated polysaccharide AHD and its underlying mechanisms were studied in renovascular hypertensive rats (RHR) [two-kidney one clip,Goldblatt(2-K 1C)J. AHD were given orally at doses of 12.5, 25,50mg·kg～-1 once a day for five weeks,simultaneously wity the initiation of the establishment of renovascular hypertensive model. Serum nitric oxide(NO) was determined with NO kit,and plasma Angiotensin E (Ang Ⅱ ) and Eneothelin (ET) Were measured by radioimmumoassays. The results indicated that AHD decreased arteial blood pressure in a dose-dependent manner. Moreover, nitric oxide (NO) contents in serum were dose-dependently elevated,accompanied by dramatic reduction in Ang Ⅱ and ET contents. These findings suggested that AHD exerted its hypotensive activity by enhancing tye release of NO,followed by reduction in production of boty ANG Ⅱ and ET in vivo.
出处
《中国海洋药物》
CAS
CSCD
2001年第2期23-26,共4页
Chinese Journal of Marine Drugs
关键词
肾血管性高血压
大鼠
海洋硫酸多糖AHD
降压作用
一氧化氮
血管紧张素Ⅱ
内皮素
Renovascular hypertensive rats (RHR)
Marine sulfated polysaccharide AHD
Hypotensive effect,Nitric oxide (NO)
Angiotensin (Ang Ⅱ )
Endothelin(ET)
