摘要
目的:研究药食两用紫红曲Monascus purpureus的化学成分。方法:应用各种色谱技术分离纯化,用MS和NMR分析确定化合物结构。结果:从紫红曲乙醇提取物的石油醚部分分离得到8个化合物,分别鉴定为:豆甾-4-烯-3-酮(1),3-oxo-24-methyl-enecycloarane(2),豆甾醇(3),7β-羟基豆甾醇(4),3β-羟基豆甾-5烯-7-酮(5),3β-羟基豆甾-5,22-二烯-7-酮(6),5α,8α-过氧麦角甾-6,22-二烯-3β-醇(7),β-谷甾醇(8)。结论:以上8个化合物除化合物3和7外,其余均为首次从红曲菌属代谢产物中分离得到。
Objective： To study the chemical constituents of Monascus purpureus metabolite. Method： The compounds were isolated by column chromatography methods, and their structures were determined by spectroscopic methods. Result： Eight compounds were isolated from the petroleum ether fraction of ethanolic extract and elucidated as stigmast-4-en-3-one （ 1）, 3-oxo-24-methylenecy- cloarane （2）, stigmasterol （3）, 7β-hydroxystigmasterol （ 4 ）, 3β-hydroxystigrnast-5 -en-7 -one （ 5 ）, 3β-hydroxystigmast-5,22 -dien-7 - one （6）, 5α,8α-epidioxyergosta-6,22-dien-3β-ol （7）, sitosterol （8）. Conclusion： All of the compounds were isolated from this genu for the first time except compound 3 and 7.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2009年第14期1809-1811,共3页
China Journal of Chinese Materia Medica
基金
北京市教委面上项目(KM200811417009)
北京市优秀人才培养项目(20061D0501600234)
北京联合大学生物活性物质与功能食品北京市重点实验室项目(LD-KZ-0605)
关键词
红曲菌代谢产物
紫红曲
化学成分
甾体
metabolites of Monascus
Monascus purpureus
chemical constituents
steroid
