摘要
目的 :探讨内镜活检组织CC44v6检测对胃癌转移的诊断价值。方法 :采用免疫组化方法检测胃癌活检组织和对照组织中CD44v6的表达。结果 :慢性胃炎、胃溃疡、胃腺瘤和胃癌活检组织中CD44v6的表达阳性率分别为 0 % ,5 .3% ,11.8%和 6 2 .8%。胃癌转移组活检组织CD44v6阳性表达率为 80 .7% ,高于无转移组(2 7.6 % ) ,具有高度显著性差异 (P <0 .0 0 1) ,癌前病变即开始逐渐出现高表达趋势。结论 :CD44v6与肿瘤的转移相关 ,胃癌活检组织中CD44v6蛋白表达可作为预测胃癌转移潜能的生物学指标并在术前决策方面有临床价值。
Objective:To evaluate the diagnostic signficance of molecule adhesion CD44 splice variant 6(CD44v6) in diseased gastric mucosa and cancerous tissues from endoscopic specimens.Methods:Expression of CD44v6 protein was detected in 86 cases of gastric carcinoma(GC) and 10 cases of chronic gastritis and 17 cases gastric polyp paraffin embedded endoscopic tissue by immunohistochemistry.Results:CD44v6 was detected in 0% of chronic gastritis,5.3% of gastric ulcer,11.8% of gastric polyp and 62.8% of GC.Compared with the control tissue,the expression of CD44v6 increased significantly in the carcinoma tissue (P<0.001).The expression of CD44v6 also increased significantly in GC with metastasis(P<0.001).The expression of CD44v6 increased significantly in the premalignant tissue.Conclusion:expression of CD44v6 is correlated with metastasis of GC.CD44v6 in cancerous tissues from endoscopic specimens may be a useful marker in predicting the metastatic potential of GC and have a significant value in making decision before surgical treatment.
出处
《中国内镜杂志》
CSCD
2001年第2期27-29,共3页
China Journal of Endoscopy
