摘要
目的 :观察缓激肽 (BK)对血浆、组织超氧化物歧化酶 (SOD)活性的影响 ,探讨 BK对心肌保护作用的机制。方法 :采用兔缺血再灌注模型 ,分别给予缺血再灌注、缺血再灌注加 BK、缺血再灌注加 BK及 HOE140处理。测定处理后 2 4h的血浆、组织丙二醛 (MDA)含量及 SOD的活性。结果 :与对照组相比 ,BK组 MDA含量明显降低 ,Mn SOD活性明显升高。结论 :BK能够增强 2 4h后兔血浆、组织 SOD活性 ,从而对缺血再灌注心肌具有保护作用。
AIM: To investigate the influence of bradykinin(BK) to plasma or myocardial malondialdehyde(MDA) level or superoxide dismutase(SOD) activity in rabbits with acute myocardial infarction, and to study the protection mechanism of BK to myocardium. METHODS: The ischemia reperfusion animal models were constructed and the animal were given BK,HOE140 or BK+HOE140 respectively. After 24 h, plasma or myocardial MDA level and SOD activity were measured. RESULTS:Contrasting with those in control group, in BK group the plasma MDA level decreased significantly and MnSOD activity increased significantly. CONCLUSION: BK can reduce plasma and myocardial MDA level and augment MnSOD activity.
出处
《心脏杂志》
CAS
2001年第2期109-111,共3页
Chinese Heart Journal
关键词
心肌缺血再灌注
缓激肽
超氧化物歧化酶
myocardial ischemia reperfusion
bradykinin
superoxide dismutase
