摘要
目的和方法：通过在体兔心肌缺血再灌注模型探讨缓激肽（ＢＫ） 对缺血再灌注心肌的延迟性保护。结果：ＢＫ 显著降低了２４ ｈ 后的心肌梗塞面积及血清肌酸磷酸激酶水平；多粘菌素Ｂ（ｐｏｌｙｍｙｘｉｎ Ｂ） － 蛋白激酶Ｃ 抑制剂，抑制了ＢＫ 的心肌保护作用。结论：ＢＫ 具有延迟性心肌保护作用，这一作用是通过ＰＫＣ
AIM and METHOD:The delayed cardioprotective action of bradykinin was studied in the open-chest anesthetized rabbits. RESULTS:The myocardial infarction area volume and serum levels of creatine phosphatekinase were reduced significantly after 24 hours of bradykinin infusion; the cardioprotective role of bradykinin was abolished by polymyxin B (a protein kinase C antagonist). CONCLUSION:Bradykinin can induce delayed cardioprotective action which is dependent on protein kinase C.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1999年第11期997-998,共2页
Chinese Journal of Pathophysiology
